Statistics of Primera División Uruguaya in season 1959.
It was contested by 10 teams, and Peñarol won the championship.
| Pos | Club | P | W | D | L | GF | GA | Pts |
| 1 | Peñarol | 18 | 12 | 2 | 4 | 35 | 20 | 26 |
| 2 | Nacional | 18 | 11 | 4 | 3 | 33 | 14 | 26 |
| 3 | Racing Montevideo | 18 | 10 | 2 | 6 | 29 | 25 | 22 |
| 4 | Cerro | 18 | 8 | 3 | 7 | 31 | 32 | 19 |
| 5 | Montevideo Wanderers | 18 | 8 | 2 | 8 | 32 | 39 | 18 |
| 6 | Defensor | 18 | 6 | 4 | 8 | 34 | 35 | 16 |
| 7 | Rampla Juniors | 18 | 5 | 5 | 8 | 26 | 26 | 15 |
| 8 | Sud América | 18 | 6 | 2 | 10 | 22 | 30 | 14 |
| 9 | Liverpool | 18 | 6 | 2 | 10 | 24 | 32 | 14 |
| 10 | Danubio | 18 | 3 | 4 | 11 | 19 | 32 | 10 |
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